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But a current spate of disquieting clinical trials involving highprofile drugs including Avandia (rosiglitazone) is prompting researchers to reevaluate this reliance on surrogate markers (see 'Surrogates beneath suspicion'). "It's been a watershed year," says Harlan Krumholtz, a cardiologist at Yale University. "It's shaking assumptions about how we needs louis vuitton uk bechristian louboutin salethese drugs."
Nobody is saying that surrogate indicators must be abandoned altogether. Several well known drugs around the market right now, including the breast cancer drug Gleevac (imatinib) and HIV fighting antiretrovirals, had louis vuitton outlet uk approved depending on surrogate endpoints, and scandals are uncommon. "You do not desire to deprive the public of a drug that possibly operates," says Arthur Schatzkin, chief of nutritional epidemiology at the National Cancer Institute in Bethesda, Maryland. "On the other hand, you do not desire to place one thing on the market place which is dangerous. That is the type of thing that individuals at the FDA [Food and Drug Administration] tear their hair out over."
One difficulty may be the struggle to show that achristian louboutin outlet ukis causally connected to illness out come, as an alternative to merely a correlate. Simply because patients with flu have a fever, as an louis vuitton uk bags sale, doesn't mean that treating the fever will clear the infection. Absolute self-confidence inside a surrogate needs comprehensive information of the pathways top to dis ease.
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